Ontology highlight
ABSTRACT:
SUBMITTER: Ikeda K
PROVIDER: S-EPMC5727902 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Ikeda Kenji K Kang Qianqian Q Yoneshiro Takeshi T Camporez Joao Paulo JP Maki Hiroko H Homma Mayu M Shinoda Kosaku K Chen Yong Y Lu Xiaodan X Maretich Pema P Tajima Kazuki K Ajuwon Kolapo M KM Soga Tomoyoshi T Kajimura Shingo S
Nature medicine 20171113 12
Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent thermogenic mechanism in beige fat that involves enhanced ATP-dependent Ca<sup>2+</sup> cycling by sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase 2b (SERCA2b) and ryanodine receptor 2 (RyR2). Inhibition of SERCA2b impairs UCP1-independent beige fat thermogenesis in humans and mice as well as in pigs, a species th ...[more]