Ontology highlight
ABSTRACT:
SUBMITTER: Takata N
PROVIDER: S-EPMC5728169 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cell reports 20171101 6
Recent advances in self-organizing, 3-dimensional tissue cultures of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) provided an in vitro model that recapitulates many aspects of the in vivo developmental steps. Using Rax-GFP-expressing ESCs, newly generated Six3<sup>-/-</sup> iPSCs, and conditional null Six3<sup>delta/f</sup>;Rax-Cre ESCs, we identified Six3 repression of R-spondin 2 (Rspo2) as a required step during optic vesicle morphogenesis and neuroretina differentia ...[more]