Ontology highlight
ABSTRACT:
SUBMITTER: Zufferey A
PROVIDER: S-EPMC5728336 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Zufferey Anne A Speck Edwin R ER Machlus Kellie R KR Aslam Rukhsana R Guo Li L McVey Mark J MJ Kim Michael M Kapur Rick R Boilard Eric E Italiano Joseph E JE Semple John W JW
Blood advances 20170908 20
Megakaryocytes (MKs) are bone marrow-derived cells that are primarily responsible for generating platelets for the maintenance of hemostasis. Although MK can variably express major histocompatibility complex (MHC) class I and II molecules during their differentiation, little is known whether they can elicit nonhemostatic immune functions such as T-cell activation. Here, we demonstrate that mature CD34<sup>-</sup> MHC class II<sup>-</sup> CD41<sup>+</sup> MKs can endocytose exogenous ovalbumin (O ...[more]