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Interleukin-10 gene rs1800896 polymorphism increases risk of acute pancreatitis.

ABSTRACT: The association between interleukin-10 (IL-10) gene rs1800896 polymorphism and susceptibility to acute pancreatitis (AP) has been investigated in several studies, but with contradictory findings. Therefore, a comprehensive meta-analysis is needed to assess the strength of such association.Literatures on PubMed, EMBASE, and CNKI were searched to identify relevant studies. The strength of association between IL-10 gene rs1800896 polymorphism and AP risk was assessed using pooled odds ratios and 95% confidence intervals.Totally 7 case-control studies involving 1527 cases and 1511 controls were identified. Analyses proved that IL-10 gene rs1800896 polymorphism was significantly associated with an increased risk of AP. Stratification analysis of ethnicity found such significant association only among Asians, but not Caucasians.IL-10 gene rs1800896 polymorphism increases the risk of AP.

SUBMITTER: Zhou H

PROVIDER: S-EPMC5728818 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Interleukin-10 gene rs1800896 polymorphism increases risk of acute pancreatitis.

Zhou Hongmei H Liu Ailing A Zhou Bingzhi B Zhao Cunxin C Jin Guangjun G

Medicine 20171201 48

<h4>Background</h4>The association between interleukin-10 (IL-10) gene rs1800896 polymorphism and susceptibility to acute pancreatitis (AP) has been investigated in several studies, but with contradictory findings. Therefore, a comprehensive meta-analysis is needed to assess the strength of such association.<h4>Methods</h4>Literatures on PubMed, EMBASE, and CNKI were searched to identify relevant studies. The strength of association between IL-10 gene rs1800896 polymorphism and AP risk was asses ...[more]

PMID: 29310417

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