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Interleukin-10 gene rs1800896 polymorphism increases risk of acute pancreatitis.

ABSTRACT: The association between interleukin-10 (IL-10) gene rs1800896 polymorphism and susceptibility to acute pancreatitis (AP) has been investigated in several studies, but with contradictory findings. Therefore, a comprehensive meta-analysis is needed to assess the strength of such association.Literatures on PubMed, EMBASE, and CNKI were searched to identify relevant studies. The strength of association between IL-10 gene rs1800896 polymorphism and AP risk was assessed using pooled odds ratios and 95% confidence intervals.Totally 7 case-control studies involving 1527 cases and 1511 controls were identified. Analyses proved that IL-10 gene rs1800896 polymorphism was significantly associated with an increased risk of AP. Stratification analysis of ethnicity found such significant association only among Asians, but not Caucasians.IL-10 gene rs1800896 polymorphism increases the risk of AP.

SUBMITTER: Zhou H

PROVIDER: S-EPMC5728818 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Interleukin-10 gene rs1800896 polymorphism increases risk of acute pancreatitis.

Zhou Hongmei H Liu Ailing A Zhou Bingzhi B Zhao Cunxin C Jin Guangjun G

Medicine 20171201 48

<h4>Background</h4>The association between interleukin-10 (IL-10) gene rs1800896 polymorphism and susceptibility to acute pancreatitis (AP) has been investigated in several studies, but with contradictory findings. Therefore, a comprehensive meta-analysis is needed to assess the strength of such association.<h4>Methods</h4>Literatures on PubMed, EMBASE, and CNKI were searched to identify relevant studies. The strength of association between IL-10 gene rs1800896 polymorphism and AP risk was asses ...[more]

PMID: 29310417

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Project description:Background: The interleukin10 (IL-10) gene polymorphisms have been indicated to be associated with breast cancer (BC) risk, but the findings are still controversial. To derive a more precise evaluation, we performed a comprehensive meta-analysis. Methods: A systematic literature search was conducted using PubMed, Embase, CNKI, China biomedical (CBM), and Google Scholar to 29 March 2020. Revman5.3 and Stata 12.0 software analyzed the data, and the strength of the association was identified using the odds ratio (OR) and the corresponding 95% confidence interval (CI). Results: A total of 23 studies (7,250 cancer cases and 7,675 case-free controls) were included in this meta-analysis. The results show that IL-10 gene polymorphisms were significantly correlated with BC risk based on subgroup analysis by ethnicity. The IL-10 rs1800896 polymorphism was significantly associated with the risk of BC in Asians (G vs. A: OR = 0.78, 95% CI = 0.65-0.95, p = 0.01; GG vs. AA: OR = 0.51, 95% CI = 0.31-0.84, p = 0.007; GA vs. AA: OR = 0.6, 95% CI = 0.44-0.81, p = 0.0009; GG + GA vs. AA: OR = 0.6, 95% CI = 0.45-0.81, p = 0.0007); Moreover, an increased BC risk in Asians were also associated with the IL-10 rs1800872 polymorphism (AA vs CC: OR = 0.74, 95% CI = 0.55-0.99, p = 0.04; A vs C: OR = 0.85, 95% CI = 0.74-0.98, p = 0.03). In addition, The IL-10 rs1800871 (CT vs. TT: OR = 1.8, 95% CI = 1.03-3.13, p = 0.04) and rs1800872 polymorphism (A vs C: OR = 0.65, 95% CI 0.43-0.98, p = 0.04) were associated with BC risk in Caucasians. Conclusion: Collectively, this meta-analysis demonstrated that IL-10 rs1800896 and rs1800872 (AA vs. CC; A vs. C) polymorphisms significantly increased the risk of BC in Asians, while the rs1800871 and rs1800872 (A vs. C) were associated with the risk of BC in Caucasians. Therefore, this may provide new ideas for predicting and diagnosing BC susceptibility through the detection of IL-10 gene polymorphism. Systematic Review Registration: [https://www.crd.york.ac.uk/ PROSPERO], identifier [CRD42021266635].

Dataset Information

Interleukin-10 gene rs1800896 polymorphism increases risk of acute pancreatitis.

Publications

Interleukin-10 gene rs1800896 polymorphism increases risk of acute pancreatitis.

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