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Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis.

ABSTRACT: OBJECTIVE:To evaluate the correlation between interleukin 10 (IL-10) -1082A/G polymorphism (rs1800896) and breast cancers by performing a meta-analysis. METHODS:The Embase and Medline databases were searched through 1 September 2018 to identify qualified articles. Odds ratios (OR) and corresponding 95% confidence intervals (CIs) were applied to evaluate associations. RESULTS:In total, 14 case-control studies, including 5320 cases and 5727 controls, were analyzed. We detected significant associations between the IL10 -1082 G/G genotype and risk of breast cancer (AA?+?AG vs. GG: OR?=?0.88, 95% CI?=?0.80-0.97). Subgroup analyses confirmed a significant association in Caucasian populations (OR?=?0.89, 95% CI?=?0.80-0.99), in population-based case-control studies (OR?=?0.87, 95% CI?=?0.78-0.96), and in studies with ?500 subjects (OR?=?0.88, 95% CI?=?0.79-0.99) under the recessive model (AA?+?AG vs. GG). No associations were found in Asian populations. CONCLUSIONS:The IL10 -1082A/G polymorphism is associated with an increased risk of breast cancer. The association between IL10 -1082 G/G genotype and increased risk of breast cancer is more significant in Caucasians, in population-based studies, and in larger studies.

SUBMITTER: Zhu Z

PROVIDER: S-EPMC7218478 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis.

Zhu ZiYin Z Liu Ji-Bin JB Liu Xi X Qian LinXue L

The Journal of international medical research 20200401 4

<h4>Objective</h4>To evaluate the correlation between interleukin 10 (IL-10) -1082A/G polymorphism (rs1800896) and breast cancers by performing a meta-analysis.<h4>Methods</h4>The Embase and Medline databases were searched through 1 September 2018 to identify qualified articles. Odds ratios (OR) and corresponding 95% confidence intervals (CIs) were applied to evaluate associations.<h4>Results</h4>In total, 14 case-control studies, including 5320 cases and 5727 controls, were analyzed. We detecte ...[more]

PMID: 32349574

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Project description:Background: The interleukin10 (IL-10) gene polymorphisms have been indicated to be associated with breast cancer (BC) risk, but the findings are still controversial. To derive a more precise evaluation, we performed a comprehensive meta-analysis. Methods: A systematic literature search was conducted using PubMed, Embase, CNKI, China biomedical (CBM), and Google Scholar to 29 March 2020. Revman5.3 and Stata 12.0 software analyzed the data, and the strength of the association was identified using the odds ratio (OR) and the corresponding 95% confidence interval (CI). Results: A total of 23 studies (7,250 cancer cases and 7,675 case-free controls) were included in this meta-analysis. The results show that IL-10 gene polymorphisms were significantly correlated with BC risk based on subgroup analysis by ethnicity. The IL-10 rs1800896 polymorphism was significantly associated with the risk of BC in Asians (G vs. A: OR = 0.78, 95% CI = 0.65-0.95, p = 0.01; GG vs. AA: OR = 0.51, 95% CI = 0.31-0.84, p = 0.007; GA vs. AA: OR = 0.6, 95% CI = 0.44-0.81, p = 0.0009; GG + GA vs. AA: OR = 0.6, 95% CI = 0.45-0.81, p = 0.0007); Moreover, an increased BC risk in Asians were also associated with the IL-10 rs1800872 polymorphism (AA vs CC: OR = 0.74, 95% CI = 0.55-0.99, p = 0.04; A vs C: OR = 0.85, 95% CI = 0.74-0.98, p = 0.03). In addition, The IL-10 rs1800871 (CT vs. TT: OR = 1.8, 95% CI = 1.03-3.13, p = 0.04) and rs1800872 polymorphism (A vs C: OR = 0.65, 95% CI 0.43-0.98, p = 0.04) were associated with BC risk in Caucasians. Conclusion: Collectively, this meta-analysis demonstrated that IL-10 rs1800896 and rs1800872 (AA vs. CC; A vs. C) polymorphisms significantly increased the risk of BC in Asians, while the rs1800871 and rs1800872 (A vs. C) were associated with the risk of BC in Caucasians. Therefore, this may provide new ideas for predicting and diagnosing BC susceptibility through the detection of IL-10 gene polymorphism. Systematic Review Registration: [https://www.crd.york.ac.uk/ PROSPERO], identifier [CRD42021266635].

Dataset Information

Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis.

Publications

Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis.

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