Ontology highlight
ABSTRACT:
SUBMITTER: Gavile CM
PROVIDER: S-EPMC5729629 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Gavile Catherine M CM Barwick Benjamin G BG Newman Scott S Neri Paola P Nooka Ajay K AK Lonial Sagar S Lee Kelvin P KP Boise Lawrence H LH
Blood advances 20171116 25
Although prognosis for patients with multiple myeloma has improved over the past decade, research toward discovery of new therapeutic avenues is important and could lead to a cure for this plasma cell malignancy. Here we show that blocking the CD28-CD86 pathway via silencing of either CD28 or CD86 leads to myeloma cell death. Inhibiting this pathway leads to downregulation of integrins and IRF4, a known myeloma survival factor. Our data also indicate that CD86, the canonical ligand in this pathw ...[more]