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Signaling Pathway Mediating Myeloma Cell Growth and Survival.

ABSTRACT: The multiple myeloma (MM) bone marrow (BM) microenvironment consists of different types of accessory cells. Both soluble factors (i.e., cytokines) secreted from these cells and adhesion of MM cells to these cells play crucial roles in activation of intracellular signaling pathways mediating MM cell growth, survival, migration, and drug resistance. Importantly, there is crosstalk between the signaling pathways, increasing the complexity of signal transduction networks in MM cells in the BM microenvironment, highlighting the requirement for combination treatment strategies to blocking multiple signaling pathways.

SUBMITTER: Hideshima T

PROVIDER: S-EPMC7827005 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Signaling Pathway Mediating Myeloma Cell Growth and Survival.

Hideshima Teru T Anderson Kenneth C KC

Cancers 20210108 2

The multiple myeloma (MM) bone marrow (BM) microenvironment consists of different types of accessory cells. Both soluble factors (i.e., cytokines) secreted from these cells and adhesion of MM cells to these cells play crucial roles in activation of intracellular signaling pathways mediating MM cell growth, survival, migration, and drug resistance. Importantly, there is crosstalk between the signaling pathways, increasing the complexity of signal transduction networks in MM cells in the BM microe ...[more]

PMID: 33435632

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