Ontology highlight
ABSTRACT:
SUBMITTER: Kojima R
PROVIDER: S-EPMC5730048 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Kojima Ryosuke R Scheller Leo L Fussenegger Martin M
Nature chemical biology 20171113 1
The ability to engineer custom cell-contact-sensing output devices into human nonimmune cells would be useful for extending the applicability of cell-based cancer therapies and for avoiding risks associated with engineered immune cells. Here we have developed a new class of synthetic T-cell receptor-like signal-transduction device that functions efficiently in human nonimmune cells and triggers release of output molecules specifically upon sensing contact with a target cell. This device employs ...[more]