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The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.

ABSTRACT: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects.Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied.The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.

SUBMITTER: Kohli I

PROVIDER: S-EPMC5730054 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.

Kohli Indermeet I Shafi Rubina R Isedeh Prescilia P Griffith James L JL Al-Jamal Mohammed S MS Silpa-Archa Narumol N Jackson Bradford B Athar Mohammed M Kollias Nikiforos N Elmets Craig A CA Lim Henry W HW Hamzavi Iltefat H IH

Journal of the American Academy of Dermatology 20170322 1

<h4>Background</h4>There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.<h4>Objective</h4>This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).<h4>Methods</h4>In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Eval ...[more]

PMID: 28341348

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Project description:ObjectivesTo measure the diagnostic accuracy, timeliness, and ease of use of Ceribell rapid response electroencephalography. We assessed physicians' diagnostic assessments and treatment plans before and after rapid response electroencephalography assessment. Primary outcomes were changes in physicians' diagnostic and therapeutic decision making and their confidence in these decisions based on the use of the rapid response electroencephalography system. Secondary outcomes were time to electroencephalography, setup time, ease of use, and quality of electroencephalography data.DesignProspective multicenter nonrandomized observational study.SettingICUs in five academic hospitals in the United States.SubjectsPatients with encephalopathy suspected of having nonconvulsive seizures and physicians evaluating these patients.InterventionsPhysician bedside assessment of sonified electroencephalography (30 s from each hemisphere) and visual electroencephalography (60 s) using rapid response electroencephalography.Measurements and main resultsPhysicians (29 fellows or residents, eight attending neurologists) evaluated 181 ICU patients; complete clinical and electroencephalography data were available in 164 patients (average 58.6 ± 18.7 yr old, 45% females). Relying on rapid response electroencephalography information at the bedside improved the sensitivity (95% CI) of physicians' seizure diagnosis from 77.8% (40.0%, 97.2%) to 100% (66.4%, 100%) and the specificity (95% CI) of their diagnosis from 63.9% (55.8%, 71.4%) to 89% (83.0%, 93.5%). Physicians' confidence in their own diagnosis and treatment plan were also improved. Time to electroencephalography (median [interquartile range]) was 5 minutes (4-10 min) with rapid response electroencephalography while the conventional electroencephalography was delayed by several hours (median [interquartile range] delay = 239 minutes [134-471 min] [p < 0.0001 using Wilcoxon signed rank test]). The device was rated as easy to use (mean ± SD: 4.7 ± 0.6 [1 = difficult, 5 = easy]) and was without serious adverse effects.ConclusionsRapid response electroencephalography enabled timely and more accurate assessment of patients in the critical care setting. The use of rapid response electroencephalography may be clinically beneficial in the assessment of patients with high suspicion for nonconvulsive seizures and status epilepticus.

Dataset Information

The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.

Publications

The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.

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