Ontology highlight
ABSTRACT:
SUBMITTER: Borgo C
PROVIDER: S-EPMC5730587 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Borgo Christian C Milan Gabriella G Favaretto Francesca F Stasi Fabio F Fabris Roberto R Salizzato Valentina V Cesaro Luca L Belligoli Anna A Sanna Marta M Foletto Mirto M Prevedello Luca L Vindigni Vincenzo V Bardini Romeo R Donella-Deana Arianna A Vettor Roberto R
Scientific reports 20171214 1
Insulin plays a major role in glucose metabolism and insulin-signaling defects are present in obesity and diabetes. CK2 is a pleiotropic protein kinase implicated in fundamental cellular pathways and abnormally elevated in tumors. Here we report that in human and murine adipocytes CK2-inhibition decreases the insulin-induced glucose-uptake by counteracting Akt-signaling and GLUT4-translocation to the plasma membrane. In mice CK2 acts on insulin-signaling in adipose tissue, liver and skeletal mus ...[more]