Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity.

ABSTRACT:

Objective

Although debated, metabolic health characterizes 10-25% of obese individuals and reduces risk of developing life-threatening co-morbidities. Adipose tissue is a recognized endocrine organ important for the maintenance of whole-body metabolic health. Adipocyte transcriptional signatures of healthy and unhealthy obesity are largely unknown.

Methods

Here, we used a small cohort of highly characterized obese individuals discordant for metabolic health, characterized their adipocytes transcriptional signatures, and cross-referenced them to mouse phenotypic and human GWAs databases.

Results and conclusions

Our study showed that glucose intolerance and insulin resistance co-operate to remodel adipocyte transcriptome. We also identified the Nuclear Export Mediator F

SUBMITTER: Gerlini R 

PROVIDER: S-EPMC6308911 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature