Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity.
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ABSTRACT: Objective
Although debated, metabolic health characterizes 10-25% of obese individuals and reduces risk of developing life-threatening co-morbidities. Adipose tissue is a recognized endocrine organ important for the maintenance of whole-body metabolic health. Adipocyte transcriptional signatures of healthy and unhealthy obesity are largely unknown.Methods
Here, we used a small cohort of highly characterized obese individuals discordant for metabolic health, characterized their adipocytes transcriptional signatures, and cross-referenced them to mouse phenotypic and human GWAs databases.Results and conclusions
Our study showed that glucose intolerance and insulin resistance co-operate to remodel adipocyte transcriptome. We also identified the Nuclear Export Mediator Factor (NEMF) and the Ectoderm-Neural Cortex 1 (ENC1) as novel potential targets in the management of metabolic health in human obesity.
SUBMITTER: Gerlini R
PROVIDER: S-EPMC6308911 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity.
Gerlini R R Berti L L Darr J J Lassi M M Brandmaier S S Fritsche L L Scheid F F Böhm A A Königsrainer A A Grallert H H Häring H U HU Hrabě de Angelis M M Staiger H H Teperino R R
Molecular metabolism 20180919
<h4>Objective</h4>Although debated, metabolic health characterizes 10-25% of obese individuals and reduces risk of developing life-threatening co-morbidities. Adipose tissue is a recognized endocrine organ important for the maintenance of whole-body metabolic health. Adipocyte transcriptional signatures of healthy and unhealthy obesity are largely unknown.<h4>Methods</h4>Here, we used a small cohort of highly characterized obese individuals discordant for metabolic health, characterized their ad ...[more]
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