Ontology highlight
ABSTRACT:
SUBMITTER: Mesquita FS
PROVIDER: S-EPMC5731514 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Mesquita Francisco Sarmento FS Brito Cláudia C Cabanes Didier D Sousa Sandra S
Communicative & integrative biology 20170928 5-6
Following damage by pore forming toxins (PFTs) host cells engage repair processes and display profound cytoskeletal remodeling and concomitant plasma membrane (PM) blebbing. We have recently demonstrated that host cells utilize similar mechanisms to control cytoskeletal dynamics in response to PFTs and during cell migration. This involves assembly of cortical actomyosin bundles, reorganisation of the endoplasmic reticulum (ER) network, and the interaction between the ER chaperone Gp96 and the mo ...[more]