Dataset Information
Maternal plasma angiogenic and inflammatory factor profiling in foetal Down syndrome.
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ABSTRACT: Objective and design
Angiogenic factors are proteins that are related to certain foetal chromosomal abnormalities. The aim of this study was to determine the concentration of 60 angiogenic factors in the plasma of women with offspring possessing trisomy 21/Down syndrome (DS).Method
After analysing karyotyping results, we selected 20 patients with foetuses possessing DS, and for the control group, we selected 28 healthy patients with uncomplicated pregnancies who delivered healthy newborns at term (i.e., 15-18 weeks of gestation). To assess the concentration of proteins in the blood plasma, we used a protein macroarray which enabled simultaneous determination of 60 angiogenic factors per sample.Results
We observed a statistically significant increase in the concentration of these five angiogenic and inflammatory factors: TGFb1 (p = 0.039), angiostatin (p = 0.0142), I-309 (p = 0.0476), TGFb3 (p = 0.0395), and VEGF-D (p = 0.0173)-compared to concentrations in patients with healthy foetuses.Conclusion
Our findings suggest that angiogenic factors may play role in DS pathogenesis.
SUBMITTER: Zbucka-Kretowska M
PROVIDER: S-EPMC5731759 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Maternal plasma angiogenic and inflammatory factor profiling in foetal Down syndrome.
PloS one 20171215 12
<h4>Objective and design</h4>Angiogenic factors are proteins that are related to certain foetal chromosomal abnormalities. The aim of this study was to determine the concentration of 60 angiogenic factors in the plasma of women with offspring possessing trisomy 21/Down syndrome (DS).<h4>Method</h4>After analysing karyotyping results, we selected 20 patients with foetuses possessing DS, and for the control group, we selected 28 healthy patients with uncomplicated pregnancies who delivered healthy ...[more]
