Ontology highlight
ABSTRACT:
SUBMITTER: Kolla V
PROVIDER: S-EPMC2774473 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Kolla Varaprasad V Jenö Paul P Moes Suzette S Tercanli Sevgi S Lapaire Olav O Choolani Mahesh M Hahn Sinuhe S
Journal of biomedicine & biotechnology 20091105
Currently no specific biomarkers exist for the screening of pregnancies at risk for Down syndrome (DS). Since a quantitative proteomic approach with isobaric labelling (iTRAQ) has recently been suggested to be highly suitable for the discovery of novel plasma biomarkers, we have now used this method to examine for potential quantitative changes in the plasma proteome of the pregnancies bearing DS fetuses in comparison to normal healthy babies. In our study, we used plasma from six women with DS ...[more]