Characterization of Toxoplasma DegP, a rhoptry serine protease crucial for lethal infection in mice.
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ABSTRACT:
SUBMITTER: Lentini G
PROVIDER: S-EPMC5731766 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Characterization of Toxoplasma DegP, a rhoptry serine protease crucial for lethal infection in mice.
Lentini Gaelle G El Hajj Hiba H Papoin Julien J Fall Gamou G Pfaff Alexander W AW Tawil Nadim N Braun-Breton Catherine C Lebrun Maryse M
PloS one 20171215 12
During the infection process, Apicomplexa discharge their secretory organelles called micronemes, rhoptries and dense granules to sustain host cell invasion, intracellular replication and to modulate host cell pathways and immune responses. Herein, we describe the Toxoplasma gondii Deg-like serine protein (TgDegP), a rhoptry protein homologous to High temperature requirement A (HtrA) or Deg-like family of serine proteases. TgDegP undergoes processing in both types I and II strains as most of the ...[more]
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