Ontology highlight
ABSTRACT:
SUBMITTER: Fustaino V
PROVIDER: S-EPMC5732732 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Fustaino Valentina V Presutti Dario D Colombo Teresa T Cardinali Beatrice B Papoff Giuliana G Brandi Rossella R Bertolazzi Paola P Felici Giovanni G Ruberti Giovina G
Oncotarget 20170922 61
Increasing evidence points to a key role played by epithelial-mesenchymal transition (EMT) in cancer progression and drug resistance. In this study, we used <i>wet</i> and <i>in silico</i> approaches to investigate whether EMT phenotypes are associated to resistance to target therapy in a non-small cell lung cancer model system harboring activating mutations of the epidermal growth factor receptor. The combination of different analysis techniques allowed us to describe intermediate/hybrid and co ...[more]