Ontology highlight
ABSTRACT:
SUBMITTER: Lalani AA
PROVIDER: S-EPMC5732739 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Lalani Aly-Khan A AA Gray Kathryn P KP Albiges Laurence L Callea Marcella M Pignon Jean-Christophe JC Pal Soumitro S Gupta Mamta M Bhatt Rupal S RS McDermott David F DF Atkins Michael B MB Woude G F Vande GFV Harshman Lauren C LC Choueiri Toni K TK Signoretti Sabina S
Oncotarget 20171023 61
In preclinical models, c-Met promotes survival of renal cancer cells through the regulation of programmed death-ligand 1 (PD-L1). However, this relationship in human clear cell renal cell carcinoma (ccRCC) is not well characterized. We evaluated c-Met expression in ccRCC patients using paired primary and metastatic samples and assessed the association with PD-L1 expression and other clinical features. Areas with predominant and highest Fuhrman nuclear grade (FNG) were selected. c-Met expression ...[more]