Ontology highlight
ABSTRACT:
SUBMITTER: Xu XL
PROVIDER: S-EPMC5732859 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Xu Xiaoliang L XL Li Zhengke Z Liu Aihong A Fan Xianqun X Hu Dan-Ning DN Qi Dong-Lai DL Chitty David W DW Jia Renbing R Qui Jianping J Wang Justin Q JQ Sharaf Jake J Zou Jun J Weiss Rebecca R Huang Hongyan H Joseph Walter J WJ Ng Lily L Rosen Richard R Shen Binghui B Reid Mark W MW Forrest Douglas D Abramson David H DH Singer Samuel S Cobrinik David D Jhanwar Suresh C SC
Cancer research 20170928 24
Germline <i>RB1</i> mutations strongly predispose humans to cone precursor-derived retinoblastomas and strongly predispose mice to pituitary tumors, yet shared cell type-specific circuitry that sensitizes these different cell types to the loss of <i>RB1</i> has not been defined. Here we show that the cell type-restricted thyroid hormone receptor isoform TRβ2 sensitizes to <i>RB1</i> loss in both settings by antagonizing the widely expressed and tumor-suppressive TRβ1. TRβ2 promoted expression of ...[more]