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Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis.

ABSTRACT: Acute pancreatitis (AP) is a complex disease that results in significant morbidity and mortality. For many decades, it has compelled researchers to explore the exact pathogenesis and the understanding of the pathogenesis of AP has progressed dramatically. Currently, premature trypsinogen activation and NF-?B activation for inflammation are two remarkable hypotheses for the mechanism of AP. Meanwhile, understanding of the influence of genetic polymorphisms has resulted in tremendous development in the understanding of the advancement of complex diseases. Now, genetic polymorphisms of AP have been noted gradually and many researchers devote themselves to this emerging area. In this review, we comprehensively describe genetic polymorphisms combined with the latest hypothesis of pathogenesis associated with AP.

SUBMITTER: Chen Y

PROVIDER: S-EPMC5733231 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis.

Chen Yong Y Xie Chao Lian CL Hu Ran R Shen Cheng Yi CY Zeng Mei M Wu Chang Qiang CQ Chen Tian Wu TW Chen Chen C Tang Meng Yue MY Xue Hua Dan HD Jin Zheng Yu ZY Zhang Xiao Ming XM

Gastroenterology research and practice 20171203

Acute pancreatitis (AP) is a complex disease that results in significant morbidity and mortality. For many decades, it has compelled researchers to explore the exact pathogenesis and the understanding of the pathogenesis of AP has progressed dramatically. Currently, premature trypsinogen activation and NF-<i>κ</i>B activation for inflammation are two remarkable hypotheses for the mechanism of AP. Meanwhile, understanding of the influence of genetic polymorphisms has resulted in tremendous develo ...[more]

PMID: 29333155

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Genetic variants in acute, acute recurrent and chronic pancreatitis affect the progression of disease in children.

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Genetic Variation in ABCC4 and CFTR and Acute Pancreatitis during Treatment of Pediatric Acute Lymphoblastic Leukemia.

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| S-EPMC8584334 | biostudies-literature

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