Ontology highlight
ABSTRACT:
SUBMITTER: Thompson AM
PROVIDER: S-EPMC5733301 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Thompson Andrew M AM Bonnet Muriel M Lee Ho H HH Franzblau Scott G SG Wan Baojie B Wong George S GS Cooper Christopher B CB Denny William A WA
ACS medicinal chemistry letters 20171113 12
A published study of structural features associated with the aerobic and anaerobic activities of 4- and 5-nitroimidazoles had found that the 3-nitro isomer of pretomanid, <b>8</b>, displayed interesting potencies, including against nitroreductase mutant <i>Mycobacterium tuberculosis</i>. However, recent nuclear magnetic resonance analyses of two trace byproducts, isolated from early process optimization studies toward a large-scale synthesis of pretomanid, raised structural assignment queries, p ...[more]