Hepatic Dysfunction Caused by Consumption of a High-Fat Diet.
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ABSTRACT:
SUBMITTER: Soltis AR
PROVIDER: S-EPMC5734865 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Hepatic Dysfunction Caused by Consumption of a High-Fat Diet.
Soltis Anthony R AR Kennedy Norman J NJ Xin Xiaofeng X Zhou Feng F Ficarro Scott B SB Yap Yoon Sing YS Matthews Bryan J BJ Lauffenburger Douglas A DA White Forest M FM Marto Jarrod A JA Davis Roger J RJ Fraenkel Ernest E
Cell reports 20171201 11
Obesity is a major human health crisis that promotes insulin resistance and, ultimately, type 2 diabetes. The molecular mechanisms that mediate this response occur across many highly complex biological regulatory levels that are incompletely understood. Here, we present a comprehensive molecular systems biology study of hepatic responses to high-fat feeding in mice. We interrogated diet-induced epigenomic, transcriptomic, proteomic, and metabolomic alterations using high-throughput omic methods ...[more]
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