Ontology highlight
ABSTRACT:
SUBMITTER: Sikorska N
PROVIDER: S-EPMC5735172 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Sikorska Natalia N Zuber Hélène H Gobert Anthony A Lange Heike H Gagliardi Dominique D
Nature communications 20171218 1
The RNA exosome provides eukaryotic cells with an essential 3'-5' exoribonucleolytic activity, which processes or eliminates many classes of RNAs. Its nine-subunit core (Exo9) is structurally related to prokaryotic phosphorolytic exoribonucleases. Yet, yeast and animal Exo9s have lost the primordial phosphorolytic capacity and rely instead on associated hydrolytic ribonucleases for catalytic activity. Here, we demonstrate that Arabidopsis Exo9 has retained a distributive phosphorolytic activity, ...[more]