Ontology highlight
ABSTRACT:
SUBMITTER: Drazkowska K
PROVIDER: S-EPMC3616716 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Drazkowska Karolina K Tomecki Rafal R Tomecki Rafal R Stodus Krystian K Kowalska Katarzyna K Czarnocki-Cieciura Mariusz M Dziembowski Andrzej A
Nucleic acids research 20130212 6
The RNA exosome is an essential ribonuclease complex involved in RNA processing and decay. It consists of a 9-subunit catalytically inert ring composed of six RNase PH-like proteins forming a central channel and three cap subunits with KH/S1 domains located at the top. The yeast exosome catalytic activity is supplied by the Dis3 (also known as Rrp44) protein, which has both endo- and exoribonucleolytic activities and the nucleus-specific exonuclease Rrp6. In vitro studies suggest that substrates ...[more]