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Association of sleep duration and quality with blood lipids: a systematic review and meta-analysis of prospective studies.

ABSTRACT: OBJECTIVES:To assess the longitudinal evidence of the relationships between sleep disturbances (of quantity and quality) and dyslipidaemia in the general population and to quantify such relationships. SETTING:Systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. METHODS:We performed a systematic search of PubMed and Embase (up to 9 September 2017), complemented with manual searches, of prospective population studies describing the association between sleep duration and quality and the incidence of dyslipidaemias. Relative risks (95% CIs) were extracted and pooled using a random effects model. Subgroup analyses by lipid type were performed. Heterogeneity and publication bias were also assessed. Quality was assessed with Downs and Black score. PARTICIPANTS:Studies were included if they were prospective, had measured sleep quantity and/or quality at baseline and either incident cases of dyslipidaemia or changes in blood lipid fractions assessed prospectively. PRIMARY OUTCOME MEASURES:Incidence of dyslipidaemia and changes in lipid fractions. Dyslipidaemia was defined as a high total cholesterol, triglycerides, low-density lipoprotein cholesterol or low high-density lipoprotein cholesterol compared with the reference group. RESULTS:Thirteen studies were identified (eight using sleep duration, four sleep quality and one both). There was heterogeneity in the sleep quality aspects and types of lipids assessed. Classification of sleep duration (per hour/groups) also varied widely. In the pooled analysis of sleep duration (6 studies, 16 cohort samples; 30?033 participants; follow-up 2.6-10 years), short sleep was associated with a risk of 1.01 (95% CI 0.93 to 1.10) of developing dyslipidaemia, with moderate heterogeneity (I2=56%, P=0.003) and publication bias (P=0.035). Long sleep was associated with a risk of 0.98 (95% CI 0.87 to 1.10) for dyslipidaemia, with heterogeneity (I2=63%, P<0.001) and no significant publication bias (P=0.248). CONCLUSION:The present analysis was unable to find supportive evidence of a significant relationship between sleep duration and the development of dyslipidaemia. However, heterogeneity and small number of studies limit the interpretation. PROSPERO REGISTRATION NUMBER:CRD42016045242.

SUBMITTER: Kruisbrink M

PROVIDER: S-EPMC5735405 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Association of sleep duration and quality with blood lipids: a systematic review and meta-analysis of prospective studies.

Kruisbrink Marlot M Robertson Wendy W Ji Chen C Miller Michelle A MA Geleijnse Johanna M JM Cappuccio Francesco P FP

BMJ open 20171214 12

<h4>Objectives</h4>To assess the longitudinal evidence of the relationships between sleep disturbances (of quantity and quality) and dyslipidaemia in the general population and to quantify such relationships.<h4>Setting</h4>Systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.<h4>Methods</h4>We performed a systematic search of PubMed and Embase (up to 9 September 2017), complemented with manual searches, of prospective po ...[more]

PMID: 29247105

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Project description:ImportanceIn the United States, 16 million family caregivers provide long-term care for patients with dementia. Although one's physical, mental, and cognitive health depends on sleep, many caregivers experience chronic stress, and stress is typically associated with worse sleep quantity and quality.ObjectiveTo quantify the extent, nature, and treatability of sleep problems in dementia caregivers.Data sourcesPubMed and Scopus databases were systematically searched for articles published through June 2018 using the following keywords: caregiver or spouse or caretaker AND sleep or circadian AND dementia or Alzheimer. Backward citation tracking was performed, and corresponding authors were contacted for additional data to conduct meta-analyses and pooled analyses.Study selectionTwo reviewers independently screened 805 studies to identify those that reported sleep duration or sleep quality in caregivers of patients with dementia.Data extraction and synthesisFollowing the PRISMA guidelines, 2 reviewers independently extracted data from all studies and conducted National Heart, Lung, and Blood Institute study quality assessments. Meta-analyses with random-effects models were performed to evaluate sleep duration, sleep quality, and sleep interventions in dementia caregivers.Main outcomes and measuresSleep quality and total sleep time were measured by polysomnography, actigraphy, and self-report.ResultsThirty-five studies were analyzed with data from 3268 caregivers (pooled mean age [SD of sample means], 63.48 [5.99] years; 76.7% female) were analyzed. Relative to age-matched control noncaregiver adults, caregivers had lower sleep durations akin to losing 2.42 to 3.50 hours each week (Hedges g?=?-0.29; 95% CI, -0.48 to -0.09; P?=?.01). Sleep quality was significantly lower in caregivers (Hedges g?=?-0.66; 95% CI, -0.89 to -0.42; P?<?.001), but caregivers who underwent sleep intervention trials had better sleep quality than caregivers who did not receive a sleep intervention (Hedges g?=?0.35; 95% CI, 0.20-0.49; P?<?.001).Conclusions and relevanceSleep debt is known to have cumulative associations with physical, mental, and cognitive health; therefore, poor sleep quality in dementia caregivers should be recognized and addressed. Although the caregiving role is stressful and cognitively demanding by its nature, better sleep quality was observed in caregivers who received low-cost behavioral interventions.

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Association of sleep duration and quality with blood lipids: a systematic review and meta-analysis of prospective studies.

Publications

Association of sleep duration and quality with blood lipids: a systematic review and meta-analysis of prospective studies.

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