Ontology highlight
ABSTRACT:
SUBMITTER: Malcolm DW
PROVIDER: S-EPMC5736382 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Malcolm Dominic W DW Freeberg Margaret A T MAT Wang Yuchen Y Sims Kenneth R KR Awad Hani A HA Benoit Danielle S W DSW
Biomacromolecules 20171011 11
pH-responsive diblock copolymers provide tailorable nanoparticle (NP) architecture and chemistry critical for siRNA delivery. Here, diblock polymers varying in first (corona) and second (core) block molecular weight (M<sub>n</sub>), corona/core ratio, and core hydrophobicity (%BMA) were synthesized to determine their effect on siRNA delivery in murine tenocytes (mTenocyte) and murine and human mesenchymal stem cells (mMSC and hMSCs, respectively). NP-mediated siRNA uptake, gene silencing, and cy ...[more]