Ontology highlight
ABSTRACT:
SUBMITTER: Jeong H
PROVIDER: S-EPMC5736594 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Jeong Heeyoon H Koh Ara A Lee Jiyoun J Park Dohyun D Lee Jung Ok JO Lee Mi Nam MN Jo Kyung-Jin KJ Tran Huynh Nguyen Khanh HNK Kim Eui E Min Byung-Sun BS Kim Hyeon Soo HS Berggren Per-Olof PO Ryu Sung Ho SH
Scientific reports 20171219 1
Insulin resistance causes type 2 diabetes; therefore, increasing insulin sensitivity is a therapeutic approach against type 2 diabetes. Activating AMP-activated protein kinase (AMPK) is an effective approach for treating diabetes, and reduced insulin receptor substrate-1 (IRS-1) protein levels have been suggested as a molecular mechanism causing insulin resistance. Thus, dual targeting of AMPK and IRS-1 might provide an ideal way to treat diabetes. We found that 15,16-dihydrotanshinone I (DHTS), ...[more]