Ontology highlight
ABSTRACT:
SUBMITTER: Mazibuko-Mbeje SE
PROVIDER: S-EPMC6387445 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Mazibuko-Mbeje Sithandiwe E SE Dludla Phiwayinkosi V PV Roux Candice C Johnson Rabia R Ghoor Samira S Joubert Elizabeth E Louw Johan J Opoku Andy R AR Muller Christo J F CJF
International journal of molecular sciences 20190201 3
We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE) reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells by modulating key effectors of insulin signalling such as phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) and AMP-activated protein kinase (AMPK). However, the effect of GRE on hepatic insulin resistance is unknown. The effects of GRE on lipid-induced hepatic insulin resistance using palmitate-exp ...[more]