Metabolomics reveals novel blood plasma biomarkers associated to the BRCA1-mutated phenotype of human breast cancer.
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ABSTRACT:
SUBMITTER: Roig B
PROVIDER: S-EPMC5736621 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Metabolomics reveals novel blood plasma biomarkers associated to the BRCA1-mutated phenotype of human breast cancer.
Roig Bàrbara B Rodríguez-Balada Marta M Samino Sara S Lam Eric W-F EW Guaita-Esteruelas Sandra S Gomes Ana R AR Correig Xavier X Borràs Joan J Yanes Oscar O Gumà Josep J
Scientific reports 20171219 1
Hereditary breast and ovarian cancer syndrome (HBOC) is partly due to the presence of mutations in the BRCA genes. Triple-negative (TN) breast cancer (BC) shares histological characteristics with germline BRCA1 mutation-associated tumours. We have investigated the metabolic profiles of human breast cancer (BC) cell lines carrying BRCA1 pathogenic mutations by non-targeted liquid chromatography coupled to mass spectrometry technology. Based on our in vitro results, we performed a targeted metabol ...[more]
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