Ontology highlight
ABSTRACT:
SUBMITTER: Rengasamy M
PROVIDER: S-EPMC5737218 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nucleic acids research 20171101 19
We observed overexpression and increased intra-nuclear accumulation of the PRMT5/WDR77 in breast cancer cell lines relative to immortalized breast epithelial cells. Utilizing mass spectrometry and biochemistry approaches we identified the Zn-finger protein ZNF326, as a novel interaction partner and substrate of the nuclear PRMT5/WDR77 complex. ZNF326 is symmetrically dimethylated at arginine 175 (R175) and this modification is lost in a PRMT5 and WDR77-dependent manner. Loss of PRMT5 or WDR77 in ...[more]