Ontology highlight
ABSTRACT:
SUBMITTER: Tian C
PROVIDER: S-EPMC5737467 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Nucleic acids research 20170801 14
Toxin-antitoxin (TA) loci are widespread in bacteria including important pathogenic species. Recent studies suggest that TA systems play a key role in persister formation. However, the persistence phenotype shows only weak dependence on the number of TA systems, i.e. they are functionally redundant. We use a mathematical model to investigate the interaction of multiple TA systems in the switching between growth and persistence. We explore two scenarios: (i) TA systems are bistable and each TA sy ...[more]