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The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.

ABSTRACT: The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its homologs FASTKD1-5 are architecturally related RNA-binding proteins, each having a different function in the regulation of mitochondrial RNA biology, from mRNA processing and maturation to ribosome assembly and translation. In this review, we outline the structure, evolution and function of these FASTK proteins and discuss the individual role that each has in mitochondrial RNA biology. In addition, we highlight the aspects of FASTK research that still require more attention.

SUBMITTER: Jourdain AA

PROVIDER: S-EPMC5737537 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.

Jourdain Alexis A AA Popow Johannes J de la Fuente Miguel A MA Martinou Jean-Claude JC Anderson Paul P Simarro Maria M

Nucleic acids research 20171101 19

The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its homologs FASTKD1-5 are architecturally related RNA-binding proteins, each having a different function in the regulation of mitochondrial RNA biology, from mRNA processing and maturation to ribosome assembly and translation. In this review, we outline the structure, evolution and function of these FASTK proteins and discuss the individual role ...[more]

PMID: 29036396

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