Ontology highlight
ABSTRACT:
SUBMITTER: Ghazanfar S
PROVIDER: S-EPMC7610653 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Ghazanfar Shila S Lin Yingxin Y Su Xianbin X Lin David Ming DM Patrick Ellis E Han Ze-Guang ZG Marioni John C JC Yang Jean Yee Hwa JYH
Nature methods 20200713 8
Single-cell genomics has transformed our ability to examine cell fate choice. Examining cells along a computationally ordered 'pseudotime' offers the potential to unpick subtle changes in variability and covariation among key genes. We describe an approach, scHOT-single-cell higher-order testing-which provides a flexible and statistically robust framework for identifying changes in higher-order interactions among genes. scHOT can be applied for cells along a continuous trajectory or across space ...[more]