Ontology highlight
ABSTRACT:
SUBMITTER: Zeng L
PROVIDER: S-EPMC5737927 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Science translational medicine 20171001 412
Sepsis, a life-threatening organ dysfunction caused by infection, is a major public health concern with limited therapeutic options. We provide evidence to support a role for anaplastic lymphoma kinase (ALK), a tumor-associated receptor tyrosine kinase, in the regulation of innate immunity during lethal sepsis. The genetic disruption of ALK expression diminishes the stimulator of interferon genes (STING)-mediated host immune response to cyclic dinucleotides in monocytes and macrophages. Mechanis ...[more]