Ontology highlight
ABSTRACT:
SUBMITTER: Lorvellec M
PROVIDER: S-EPMC5738056 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Lorvellec Maëlle M Scottoni Federico F Crowley Claire C Fiadeiro Rebeca R Maghsoudlou Panagiotis P Pellegata Alessandro Filippo AF Mazzacuva Francesca F Gjinovci Asllan A Lyne Anne-Marie AM Zulini Justine J Little Daniel D Mosaku Olukunbi O Kelly Deirdre D De Coppi Paolo P Gissen Paul P
PloS one 20171220 12
Liver transplantation is the definitive treatment of liver failure but donor organ shortage limits its availability. Stem cells are highly expandable and have the potential to differentiate into any specialist cell. Use of patient-derived induced Pluripotent Stem Cells (hiPSCs) has the additional advantage for organ regeneration therapies by removing the need for immunosuppression. We compared hepatocyte differentiation of human embryonic stem cells (hESCs) and hiPSCs in a mouse decellularised l ...[more]