Ontology highlight
ABSTRACT:
SUBMITTER: Hayer A
PROVIDER: S-EPMC6159904 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Hayer Arnold A Shao Lin L Chung Mingyu M Joubert Lydia-Marie LM Yang Hee Won HW Tsai Feng-Chiao FC Bisaria Anjali A Betzig Eric E Meyer Tobias T
Nature cell biology 20161114 12
The development and maintenance of tissues requires collective cell movement, during which neighbouring cells coordinate the polarity of their migration machineries. Here, we ask how polarity signals are transmitted from one cell to another across symmetrical cadherin junctions, during collective migration. We demonstrate that collectively migrating endothelial cells have polarized VE-cadherin-rich membrane protrusions, 'cadherin fingers', which leading cells extend from their rear and follower ...[more]