Ontology highlight
ABSTRACT:
SUBMITTER: Jamiolkowski RM
PROVIDER: S-EPMC5738495 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Jamiolkowski Ryan M RM Chen Chunlai C Cooperman Barry S BS Goldman Yale E YE
Biophysical journal 20171201 11
The pretranslocation complex of the ribosome can undergo spontaneous fluctuations of messenger RNA and transfer RNAs (tRNAs) between classical and hybrid states, and occupation of the hybrid tRNA positions has been proposed to precede translocation. The classical and hybrid state tRNA positions have been extensively characterized when the ribosome is stalled along the messenger RNA by either the absence or delayed addition of elongation factor G (EF-G), or by the presence of antibiotics or GTP a ...[more]