Ontology highlight
ABSTRACT:
SUBMITTER: Oyrer J
PROVIDER: S-EPMC5738717 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Oyrer Julia J Maljevic Snezana S Scheffer Ingrid E IE Berkovic Samuel F SF Petrou Steven S Reid Christopher A CA
Pharmacological reviews 20180101 1
Epilepsy is a common and serious neurologic disease with a strong genetic component. Genetic studies have identified an increasing collection of disease-causing genes. The impact of these genetic discoveries is wide reaching-from precise diagnosis and classification of syndromes to the discovery and validation of new drug targets and the development of disease-targeted therapeutic strategies. About 25% of genes identified in epilepsy encode ion channels. Much of our understanding of disease mech ...[more]