Ontology highlight
ABSTRACT:
SUBMITTER: Dubois F
PROVIDER: S-EPMC5739297 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20171018 26
Cell polarization and directed migration play pivotal roles in diverse physiological and pathological processes. Herein, we identify new roles for paxillin-mediated HDAC6 inhibition in regulating key aspects of cell polarization in both two-dimensional and one-dimensional matrix environments. Paxillin, by modulating microtubule acetylation through HDAC6 regulation, was shown to control centrosome and Golgi reorientation toward the leading edge, a hallmark of cell polarization to ensure directed ...[more]