Ontology highlight
ABSTRACT:
SUBMITTER: Jones MC
PROVIDER: S-EPMC3681694 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Jones Matthew C MC Machida Kazuya K Mayer Bruce J BJ Turner Christopher E CE
Molecular biology of the cell 20130424 12
The Rho family of GTPases plays an important role in coordinating dynamic changes in the cell migration machinery after integrin engagement with the extracellular matrix. Rho GTPases are activated by guanine nucleotide exchange factors (GEFs) and negatively regulated by GTPase-activating proteins (GAPs). However, the mechanisms by which GEFs and GAPs are spatially and temporally regulated are poorly understood. Here the activity of the proto-oncogene Vav2, a GEF for Rac1, RhoA, and Cdc42, is sho ...[more]