Ontology highlight
ABSTRACT:
SUBMITTER: Westbrook RM
PROVIDER: S-EPMC5739384 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Westbrook Reyhan M RM Yang Huan Le HL Langdon Jackie M JM Roy Cindy N CN Kim Jin A JA Choudhury Parichoy P PP Xue Qian-Li QL di Francesco Andrea A de Cabo Rafa R Walston Jeremy J
PloS one 20171221 12
Interleukin 10tm1Cgn (IL 10tm) mice have been utilized as a model of chronic inflammation and declining health span because of their propensity to develop chronic activation in NFkB pathways, skeletal muscle and cardiac changes, and mitochondrial dysfunction. We hypothesized that older IL 10tm frail mice would have alterations similar to frail, older humans in measured parameters of glucose metabolism, oxygen consumption (VO2), respiratory quotient (RQ), spontaneous locomotor activity, body comp ...[more]