Ontology highlight
ABSTRACT:
SUBMITTER: Fan G
PROVIDER: S-EPMC5739699 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Fan Guobiao G Ye Dan D Zhu Songcheng S Xi Jiajie J Guo Xudong X Qiao Jing J Wu Yukang Y Jia Wenwen W Wang Guiying G Fan Guohuang G Kang Jiuhong J
Oncotarget 20171120 62
Cutaneous melanoma is a highly malignant and metastatic skin cancer with high mortality. However, its underlying mechanisms remain largely unclear. Here, we found that retrotransposon-like 1 (RTL1) is highly enriched in melanoma tissue, especially in early and horizontal growth tissues. Knockdown of RTL1 in melanoma cells resulted in cell proliferation suppression; cell cycle arrest at G1 phase; and down-regulation of E2F1, CYCLIN D1, cyclin-dependent kinase 6 (CDK6) and c-MYC. Moreover, overexp ...[more]