Ontology highlight
ABSTRACT:
SUBMITTER: Li ZH
PROVIDER: S-EPMC5739732 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Li Zhi-Hua ZH Weng Xueling X Xiong Qiu-Yun QY Tu Jian-Hong JH Xiao An A Qiu Wei W Gong Yu Y Hu Er-Wei EW Huang Songyin S Cao Ya-Li YL
Oncotarget 20171106 63
miR-34a is significantly down-regulated in breast cancer tissues and cell lines, which may be correlated with breast cancer multi-drug resistance (MDR). Here, we conducted cell-based experiments and clinical studies in a cohort of 113 breast cancer samples to analyze miR-34a expression and breast cancer MDR. Expression of miR-34a is down-regulated in the multi-drug resistant MDR-MCF-7 cells compared with its parental cells. Patients with miR-34a low expression had poorer overall survival (OS) an ...[more]