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Lateral hypothalamic activity indicates hunger and satiety states in humans.

ABSTRACT: Lateral hypothalamic area (LHA) local field potentials (LFPs) were recorded in a Prader-Willi patient undergoing deep brain stimulation (DBS) for obesity. During hunger, exposure to food-related cues induced an increase in beta/low-gamma activity. In contrast, recordings during satiety were marked by prominent alpha rhythms. Based on these findings, we have delivered alpha-frequency DBS prior to and during food intake. Despite reporting an early sensation of fullness, the patient continued to crave food. This suggests that the pattern of activity in LHA may indicate hunger/satiety states in humans but attest to the complexity of conducting neuromodulation studies in obesity.

SUBMITTER: Talakoub O

PROVIDER: S-EPMC5740250 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Lateral hypothalamic activity indicates hunger and satiety states in humans.

Talakoub Omid O Paiva Raquel R RR Milosevic Matija M Hoexter Marcelo Q MQ Franco Ruth R Alho Eduardo E Navarro Jessie J Pereira José F JF Popovic Milos R MR Savage Cary C Lopes Antonio C AC Alvarenga Pedro P Damiani Durval D Teixeira Manoel J MJ Miguel Euripides C EC Fonoff Erich T ET Batistuzzo Marcelo C MC Hamani Clement C

Annals of clinical and translational neurology 20171020 12

Lateral hypothalamic area (LHA) local field potentials (LFPs) were recorded in a Prader-Willi patient undergoing deep brain stimulation (DBS) for obesity. During hunger, exposure to food-related cues induced an increase in beta/low-gamma activity. In contrast, recordings during satiety were marked by prominent alpha rhythms. Based on these findings, we have delivered alpha-frequency DBS prior to and during food intake. Despite reporting an early sensation of fullness, the patient continued to cr ...[more]

PMID: 29296618

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