Ontology highlight
ABSTRACT:
SUBMITTER: Tsao CH
PROVIDER: S-EPMC5910021 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
eLife 20180316
The fruit fly can evaluate its energy state and decide whether to pursue food-related cues. Here, we reveal that the mushroom body (MB) integrates hunger and satiety signals to control food-seeking behavior. We have discovered five pathways in the MB essential for hungry flies to locate and approach food. Blocking the MB-intrinsic Kenyon cells (KCs) and the MB output neurons (MBONs) in these pathways impairs food-seeking behavior. Starvation bi-directionally modulates MBON responses to a food od ...[more]