Ontology highlight
ABSTRACT:
SUBMITTER: Wu CG
PROVIDER: S-EPMC5741625 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Wu Cheng-Guo CG Zheng Aiping A Jiang Li L Rowse Michael M Stanevich Vitali V Chen Hui H Li Yitong Y Satyshur Kenneth A KA Johnson Benjamin B Gu Ting-Jia TJ Liu Zuojia Z Xing Yongna Y
Nature communications 20171222 1
Dynamic assembly/disassembly of signaling complexes are crucial for cellular functions. Specialized latency and activation chaperones control the biogenesis of protein phosphatase 2A (PP2A) holoenzymes that contain a common scaffold and catalytic subunits and a variable regulatory subunit. Here we show that the butterfly-shaped TIPRL (TOR signaling pathway regulator) makes highly integrative multibranching contacts with the PP2A catalytic subunit, selective for the unmethylated tail and perturbi ...[more]