Ontology highlight
ABSTRACT:
SUBMITTER: Wichgers Schreur PJ
PROVIDER: S-EPMC7173960 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Wichgers Schreur Paul J PJ van de Water Sandra S Harmsen Michiel M Bermúdez-Méndez Erick E Drabek Dubravka D Grosveld Frank F Wernike Kerstin K Beer Martin M Aebischer Andrea A Daramola Olalekan O Rodriguez Conde Sara S Brennan Karen K Kozub Dorota D Søndergaard Kristiansen Maiken M Mistry Kieran K KK Deng Ziyan Z Hellert Jan J Guardado-Calvo Pablo P Rey Félix A FA van Keulen Lucien L Kortekaas Jeroen J
eLife 20200421
The World Health Organization has included three bunyaviruses posing an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemics and for which no, or insufficient countermeasures exist. Here, we describe a broadly applicable strategy, based on llama-derived single-domain antibodies (VHHs), for the development of bunyavirus biotherapeutics. The method was validated using the zoonotic Rift Valley fever virus (RVFV) and Schmallenberg virus (SBV), an emergin ...[more]