Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC5741820 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Chen Zhihong Z Feng Xi X Herting Cameron J CJ Garcia Virginia Alvarez VA Nie Kai K Pong Winnie W WW Rasmussen Rikke R Dwivedi Bhakti B Seby Sandra S Wolf Susanne A SA Gutmann David H DH Hambardzumyan Dolores D
Cancer research 20170224 9
In glioblastoma (GBM), tumor-associated macrophages (TAM) represent up to one half of the cells of the tumor mass, including both infiltrating macrophages and resident brain microglia. In an effort to delineate the temporal and spatial dynamics of TAM composition during gliomagenesis, we used genetically engineered and GL261-induced mouse models in combination with CX3CR1<sup>GFP/WT</sup>;CCR2<sup>RFP/WT</sup> double knock-in mice. Using this approach, we demonstrated that CX3CR1<sup>Lo</sup>CCR ...[more]