Ontology highlight
ABSTRACT:
SUBMITTER: Fischer GM
PROVIDER: S-EPMC5742019 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Fischer Grant M GM Vashisht Gopal Y N YN McQuade Jennifer L JL Peng Weiyi W DeBerardinis Ralph J RJ Davies Michael A MA
Pigment cell & melanoma research 20171102 1
Melanomas are metabolically heterogeneous, and they are able to adapt in order to utilize a variety of fuels that facilitate tumor progression and metastasis. The significance of metabolism in melanoma is supported by growing evidence of impact on the efficacy of contemporary therapies for this disease. There are also data to support that the metabolic phenotypes of melanoma cells depend upon contributions from both intrinsic oncogenic pathways and extrinsic factors in the tumor microenvironment ...[more]