Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt MO
PROVIDER: S-EPMC5742071 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Schmidt Marcel Oliver MO Garman Khalid Ammar KA Lee Yong Gu YG Zuo Chong C Beck Patrick James PJ Tan Mingjun M Aguilar-Pimentel Juan Antonio JA Ollert Markus M Schmidt-Weber Carsten C Fuchs Helmut H Gailus-Durner Valerie V Hrabe de Angelis Martin M Tassi Elena E Riegel Anna Tate AT Wellstein Anton A
The Journal of investigative dermatology 20170831 1
Fibroblast growth factor-binding protein 1 (FGFBP1) is a secreted chaperone that mobilizes paracrine-acting FGFs, stored in the extracellular matrix, and presents them to their cognate receptors. FGFBP1 enhances FGF signaling including angiogenesis during cancer progression and is upregulated in various cancers. Here we evaluated the contribution of endogenous FGFBP1 to a wide range of organ functions as well as to skin pathologies using Fgfbp1-knockout mice. Relative to wild-type littermates, k ...[more]