Active maintenance of endothelial cells prevents kidney fibrosis.
Ontology highlight
ABSTRACT:
SUBMITTER: Yang SH
PROVIDER: S-EPMC5743042 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Active maintenance of endothelial cells prevents kidney fibrosis.
Yang Seung Hee SH Kim Yong Chul YC An Jung Nam JN Kim Jin Hyuk JH Lee Juhoh J Lee Hee-Yoon HY Cho Joo-Youn JY Paik Jin Ho JH Oh Yun Kyu YK Lim Chun Soo CS Kim Yon Su YS Lee Jung Pyo JP
Kidney research and clinical practice 20171231 4
<h4>Background</h4>Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents.<h4>Methods</h4>We used a unilateral ureteral obstruction mouse model of kidney fibrosis to determine whether inhibition of sEH activity reduces fibrosis, the final common pathway for chronic kidney disease.<h4>Results</h4>sEH activity was inhibited by continuous release of the inhibitor 12-(3-adamantan-1-ylureido)-dodecanoic ...[more]
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